Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29772235 | 1.00 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10459187 | 1.00 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL9945534 | 1.00 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL29674419 | 1.00 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL3360473 | 1.00 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL19509816 | 1.00 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL19509705 | 1.00 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL4287258 | 0.92 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL9945527 | 0.90 | P2RY12 (0.41) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL15892163 | 0.89 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159922-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230159922-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | US | disclosed |
| EP-4013428-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | Ionis Pharmaceuticals, Inc. (US) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021030763-A1 | MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2021-02-18 | — | — | WO | disclosed |