Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19509705 | 0.92 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL29772235 | 0.92 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL29674419 | 0.92 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL3360473 | 0.92 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL19509816 | 0.92 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL22984018 | 0.92 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9945534 | 0.92 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL10459187 | 0.92 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL15892163 | 0.87 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DADORA1 | |
| SCHEMBL15850628 | 0.87 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221807-A1 | 2' Deoxy-2'-Alkylnucleotide Containing Nucleic Acid | SIRNA THERAPEUTICS INC. (US) | 2009-09-03 | — | — | US | disclosed |
| US-20060142557-A1 | 2'-deoxy-2'alkylnucleotide containing nucleic acid | SIRNA THERAPEUTICS, INC. | 2006-06-29 | — | — | US | disclosed |
| EP-1502950-A2 | Method for purifying chemically modified RNA | RIBOZYME PHARMACEUTICALS, INC. (US) | 2005-02-02 | — | — | EP | disclosed |
| US-20020197684-A1 | 2'-deoxy-2'-alkylnucleotide containing nucleic acid | RIBOZYME PHARMACEUTICALS, INC. | 2002-12-26 | — | — | US | disclosed |
| EP-1260586-A2 | Method and reagent for inhibiting the expression of disease related genes | RIBOZYME PHARMACEUTICALS, INC. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6365374-B1 | NUCLEOTIDE STABILIZES RIBOZYMES AND ANTISENSE OLIGONUCLEOTIDES | RIBOZYME PHARMACEUTICALS, INC. | 2002-04-02 | — | — | US | disclosed |
| US-5985621-A | CAPABLE OF CLEAVING A RNA | RIBOZYME PHARMACEUTICALS, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5639647-A | USEFUL IN ENZYMETIC CLEAVAGE OF RNA OR SINGLE STRANDED DNA, AND ALSO AS ANTISENSE OLIGONUCLEOTIDES | RIBOZYME PHARMACEUTICALS, INC. (US) | 1997-06-17 | — | — | US | disclosed |
| US-5627053-A | STABILIZATION OF OLIGONUCLEOTIDES, ANTISENSE MOLECULES AND FORMING ALLYL DERIVATIVES FROM TRITYL-SILYL DERIVATIVES | RIBOZYME PHARMACEUTICALS, INC. (US) | 1997-05-06 | — | — | US | disclosed |
| EP-0746614-A1 | METHOD AND REAGENT FOR INHIBITING THE EXPRESSION OF DISEASE RELATED GENES | RIBOZYME PHARMACEUTICALS, INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995023225-A2 | METHOD AND REAGENT FOR INHIBITING THE EXPRESSION OF DISEASE RELATED GENES | RIBOZYME PHARMACEUTICALS, INC. (US) | 1995-08-31 | — | — | WO | disclosed |