SCHEMBL22984025

SCHEMBL22984025

COc1ccc(C(OC[C@H]2O[C@@H](n3cc(C)c(=O)[nH]c3=O)[C@H](OC)[C@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TYMP P19971 4/20 0.54
TK2 O00142 7/20 0.44
TK1 P04183 4/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7702801 1.00 TYMP (0.54) TYMPTK2TK1
SCHEMBL7702799 1.00 TYMP (0.54) TYMPTK2TK1
SCHEMBL16401541 0.93 TYMP (0.54) TYMPTK2TK1
SCHEMBL16401538 0.93 TYMP (0.54) TYMPTK2TK1
SCHEMBL13205014 0.92 TYMP (0.62) TYMPTK2TK1
SCHEMBL13714472 0.92 TYMP (0.62) TYMPTK2TK1
SCHEMBL15974161 0.92 TYMP (0.62) TYMPTK2TK1
SCHEMBL3069436 0.92 TYMP (0.62) TYMPTK2TK1
SCHEMBL9710318 0.92 TYMP (0.62) TYMPTK2TK1
SCHEMBL3069438 0.92 TYMP (0.62) TYMPTK2TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230159922-A1 MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF IONIS PHARMACEUTICALS, INC. (US) 2023-05-25 US disclosed
EP-4013428-A1 MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF Ionis Pharmaceuticals, Inc. (US) 2022-06-22 EP disclosed
WO-2021030763-A1 MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF IONIS PHARMACEUTICALS, INC. (US) 2021-02-18 WO disclosed