Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12380647 | 0.84 | HSD17B10 (0.50) | HSD17B10MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL2296208 | 0.82 | HPGD (0.55) | HSD17B10MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL2292402 | 0.78 | KDM4E (0.46) | HSD17B10MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL2292744 | 0.76 | ALDH1A1 (0.46) | HSD17B10MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL2294495 | 0.75 | HPGD (0.47) | HSD17B10MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL12419714 | 0.75 | HPGD (0.64) | HSD17B10MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL2295302 | 0.75 | MEN1 (0.48) | HSD17B10MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL2298664 | 0.74 | HSD17B10 (0.53) | HSD17B10MEN1HPGDKMT2AHDAC8 | |
| SCHEMBL2295162 | 0.74 | FGFR1 (0.42) | HSD17B10MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL4067156 | 0.74 | KMT2A (0.44) | HSD17B10MEN1HPGDKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003806-B2 | Integrin antagonists useful as anticancer agents | OSI Pharmaceuticals, LLC (US) | 2011-08-23 | — | — | US | disclosed |