Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.53 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.53 |
| ▸ | FES | P07332 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.46 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047900 | 0.87 | FES (0.66) | LRRK2MAPK7FESFLT3DCLK1 | |
| SCHEMBL22985944 | 0.87 | LRRK2 (0.52) | LRRK2MAPK7FESFLT3BRD4 | |
| SCHEMBL22985881 | 0.86 | MAPK7 (0.53) | LRRK2MAPK7BRD4BRDTDCLK1 | |
| SCHEMBL22985890 | 0.81 | FES (0.60) | LRRK2MAPK7FESFLT3DCLK1 | |
| SCHEMBL22985864 | 0.80 | LRRK2 (0.66) | LRRK2 | |
| SCHEMBL21099617 | 0.79 | LRRK2 (0.53) | LRRK2MAPK7BRD4BRDTDCLK1 | |
| SCHEMBL22985900 | 0.79 | FES (0.74) | LRRK2MAPK7FESFLT3DCLK1 | |
| SCHEMBL22985905 | 0.79 | FES (0.64) | FESFLT3 | |
| SCHEMBL22985878 | 0.77 | FES (0.61) | LRRK2MAPK7FESFLT3DCLK1 | |
| SCHEMBL22985876 | 0.77 | FES (0.49) | MAPK7FESFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |