Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FES | P07332 | 2/20 | 0.61 |
| ▸ | FLT3 | P36888 | 2/20 | 0.61 |
| ▸ | IGF1R | P08069 | 10/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | INSR | P06213 | 5/20 | 0.51 |
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | TTK | P33981 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | STK25 | O00506 | 1/20 | 0.48 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | CASK | O14936 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22985890 | 0.94 | FES (0.60) | FESFLT3IGF1RALKPDGFRB | |
| SCHEMBL22985900 | 0.91 | FES (0.74) | FESFLT3IGF1RALKINSR | |
| SCHEMBL22985905 | 0.88 | FES (0.64) | FESFLT3IGF1RALKINSR | |
| SCHEMBL4045834 | 0.85 | FES (0.84) | FESFLT3IGF1RALKPDGFRB | |
| SCHEMBL22985897 | 0.84 | FES (0.64) | FESFLT3IGF1RALKINSR | |
| SCHEMBL22985876 | 0.83 | FES (0.49) | FESFLT3IGF1RALKINSR | |
| SCHEMBL19921199 | 0.82 | ALK (0.49) | FESFLT3IGF1RALKPDGFRB | |
| SCHEMBL23010799 | 0.81 | EGFR (0.49) | FESFLT3IGF1RALKPDGFRB | |
| SCHEMBL22985861 | 0.80 | FES (0.59) | FESFLT3IGF1RALKPDGFRB | |
| SCHEMBL3953410 | 0.80 | FES (0.82) | FESFLT3IGF1RALKPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |