Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.63 |
| ▸ | TTK | P33981 | 3/20 | 0.55 |
| ▸ | FES | P07332 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.53 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.53 |
| ▸ | INSR | P06213 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.53 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.53 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | STK25 | O00506 | 1/20 | 0.53 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | CASK | O14936 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18018792 | 0.87 | LRRK2 (0.65) | ALKTTKFESFLT3LRRK2 | |
| SCHEMBL22985886 | 0.86 | LRRK2 (0.54) | ALKTTKLRRK2INSREGFR | |
| SCHEMBL22985891 | 0.85 | LRRK2 (0.53) | ALKTTKLRRK2INSREGFR | |
| SCHEMBL18018791 | 0.83 | LRRK2 (0.72) | ALKTTKLRRK2MAP3K9MKNK2 | |
| SCHEMBL22985862 | 0.83 | LRRK2 (0.65) | ALKTTKLRRK2INSRIGF1R | |
| SCHEMBL22985894 | 0.82 | DYRK1A (0.52) | ALKTTKLRRK2INSREGFR | |
| SCHEMBL22985869 | 0.82 | DYRK1A (0.52) | ALKTTKLRRK2INSREGFR | |
| SCHEMBL18018790 | 0.82 | ALK (0.79) | ALKTTKFESFLT3LRRK2 | |
| SCHEMBL22985920 | 0.81 | LRRK2 (0.52) | ALKTTKLRRK2INSREGFR | |
| SCHEMBL22985916 | 0.75 | ALK (0.48) | ALKTTKFESFLT3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |