Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | STK25 | O00506 | 1/20 | 0.40 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | CASK | O14936 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | MUSK | O15146 | 1/20 | 0.40 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18018792 | 0.79 | LRRK2 (0.65) | ALKPTK2TTKLRRK2INSR | |
| SCHEMBL22985863 | 0.75 | ALK (0.63) | ALKPTK2TTKLRRK2INSR | |
| SCHEMBL18018791 | 0.73 | LRRK2 (0.72) | ALKTTKLRRK2MAP3K9MKNK2 | |
| SCHEMBL18018790 | 0.69 | ALK (0.79) | ALKPTK2TTKLRRK2INSR | |
| SCHEMBL18018962 | 0.67 | LRRK2 (0.75) | TTKLRRK2CLK1CLK2CLK3 | |
| SCHEMBL22985864 | 0.67 | LRRK2 (0.66) | TTKLRRK2CLK1CLK2CLK3 | |
| SCHEMBL22985899 | 0.66 | LRRK2 (0.76) | TTKLRRK2CLK1CLK2CLK3 | |
| SCHEMBL30978788 | 0.66 | CDK7 (0.72) | ALKPTK2TTKLRRK2INSR | |
| SCHEMBL18018966 | 0.66 | LRRK2 (0.74) | TTKLRRK2CLK1CLK2CLK3 | |
| SCHEMBL22658522 | 0.65 | LRRK2 (0.50) | PTK2TTKLRRK2CLK1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |