Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.62 |
| ▸ | INSR | P06213 | 13/20 | 0.62 |
| ▸ | IGF1R | P08069 | 13/20 | 0.62 |
| ▸ | EGFR | P00533 | 6/20 | 0.58 |
| ▸ | MET | P08581 | 3/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | STK10 | O94804 | 2/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | FYN | P06241 | 2/20 | 0.58 |
| ▸ | FES | P07332 | 2/20 | 0.58 |
| ▸ | CSF1R | P07333 | 2/20 | 0.58 |
| ▸ | YES1 | P07947 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18637132 | 0.88 | ALK (0.81) | ALKINSRIGF1REGFRMET | |
| SCHEMBL18018790 | 0.86 | ALK (0.79) | ALKINSRIGF1REGFRMET | |
| SCHEMBL22985890 | 0.84 | FES (0.60) | ALKINSRIGF1REGFRMET | |
| SCHEMBL26270561 | 0.83 | ALK (0.73) | ALKINSRIGF1REGFRMET | |
| SCHEMBL21099658 | 0.83 | ALK (0.60) | ALKINSRIGF1REGFRMET | |
| SCHEMBL20367241 | 0.82 | ALK (0.74) | ALKINSRIGF1REGFRMET | |
| SCHEMBL19921194 | 0.82 | ALK (0.59) | ALKINSRIGF1REGFRMET | |
| SCHEMBL24327560 | 0.81 | ALK (0.62) | ALKINSRIGF1REGFRMET | |
| SCHEMBL22985864 | 0.81 | LRRK2 (0.66) | CLK1CLK2MAP3K9LRRK2TTK | |
| SCHEMBL21099498 | 0.79 | ALK (0.60) | ALKINSRIGF1REGFRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |