Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.72 |
| ▸ | JAK2 | O60674 | 1/20 | 0.69 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.69 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.69 |
| ▸ | TTK | P33981 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22985939 | 0.90 | LRRK2 (0.69) | LRRK2JAK2 | |
| SCHEMBL12066134 | 0.84 | LRRK2 (1.00) | LRRK2JAK2MAP3K9MKNK2TTK | |
| SCHEMBL14642106 | 0.82 | LRRK2 (0.86) | LRRK2JAK2MAP3K9MKNK2TTK | |
| SCHEMBL18018881 | 0.82 | LRRK2 (1.00) | LRRK2JAK2MAP3K9MKNK2 | |
| SCHEMBL29567607 | 0.81 | LRRK2 (1.00) | LRRK2JAK2MAP3K9MKNK2 | |
| SCHEMBL7450489 | 0.81 | LRRK2 (1.00) | LRRK2JAK2MAP3K9MKNK2TTK | |
| SCHEMBL7454021 | 0.81 | LRRK2 (1.00) | LRRK2JAK2MAP3K9MKNK2 | |
| SCHEMBL29432560 | 0.81 | LRRK2 (1.00) | LRRK2JAK2MAP3K9MKNK2 | |
| SCHEMBL7449637 | 0.81 | LRRK2 (0.84) | LRRK2JAK2MAP3K9MKNK2TTK | |
| SCHEMBL7450262 | 0.81 | LRRK2 (1.00) | LRRK2JAK2MAP3K9MKNK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |