Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.69 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22985912 | 0.90 | LRRK2 (0.72) | LRRK2JAK2 | |
| SCHEMBL7459229 | 0.81 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL14641949 | 0.81 | LRRK2 (0.82) | LRRK2JAK2 | |
| SCHEMBL31757153 | 0.81 | LRRK2 (1.00) | LRRK2SLCO1B1 | |
| SCHEMBL18018884 | 0.81 | LRRK2 (1.00) | LRRK2SLCO1B1 | |
| SCHEMBL7450050 | 0.81 | LRRK2 (1.00) | LRRK2JAK2 | |
| SCHEMBL7452897 | 0.81 | LRRK2 (1.00) | LRRK2JAK2 | |
| SCHEMBL31757155 | 0.80 | LRRK2 (0.77) | LRRK2SLCO1B1 | |
| SCHEMBL18018893 | 0.80 | LRRK2 (1.00) | LRRK2SLCO1B1 | |
| SCHEMBL31757156 | 0.80 | LRRK2 (1.00) | LRRK2SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778604-A1 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3778605-A2 | LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME | Dana Farber Cancer Institute, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |