Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30418282 | 0.93 | PARP1 (0.57) | PARP1CHEK2PARP2DHODH | |
| SCHEMBL2295375 | 0.93 | PARP1 (0.57) | PARP1CHEK2PARP2DHODH | |
| SCHEMBL2294128 | 0.93 | PARP1 (0.57) | PARP1CHEK2PARP2DHODH | |
| SCHEMBL30418224 | 0.93 | PARP1 (0.57) | PARP1CHEK2PARP2DHODH | |
| SCHEMBL2294120 | 0.93 | PARP1 (0.57) | PARP1CHEK2PARP2DHODH | |
| SCHEMBL2299796 | 0.90 | PARP1 (0.58) | PARP1PARP2DHODH | |
| SCHEMBL2297448 | 0.88 | PARP1 (0.55) | PARP1PARP2DHODH | |
| SCHEMBL30417841 | 0.87 | PARP1 (0.56) | PARP1CHEK2PARP2DHODH | |
| SCHEMBL2297910 | 0.87 | PARP1 (0.56) | PARP1CHEK2PARP2DHODH | |
| SCHEMBL2295457 | 0.86 | PARP1 (0.69) | PARP1PARP2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186877-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2009-07-23 | — | — | US | claimed |
| US-20070259937-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES | 2007-11-08 | — | — | US | claimed |
| US-7999117-B2 | Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors | ABBVIE INC. | 2011-08-16 | — | — | US | disclosed |
| US-20090186877-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2009-07-23 | — | — | US | disclosed |
| US-20070259937-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259937-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | PARP1 1/4885GRIN2B 2929/4885CHEK2 189/4885 |
| US-20090186877-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | PARP1 1/4885GRIN2B 2929/4885CHEK2 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.