Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 11/20 | 0.43 |
| ▸ | NPC1 | O15118 | 10/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2293498 | 0.92 | NPC1 (0.41) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2296414 | 0.91 | MAPT (0.44) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2296670 | 0.89 | NR1I2 (0.47) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2296252 | 0.89 | NR1I2 (0.47) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL5300999 | 0.87 | SMN1; SMN2 (0.50) | RAB9ANPC1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL5299923 | 0.84 | NR1I2 (0.44) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL12421967 | 0.83 | NR1I2 (0.45) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL12420930 | 0.83 | NR1I2 (0.45) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL5301184 | 0.83 | RAB9A (0.44) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2295162 | 0.83 | FGFR1 (0.42) | NR1I2RAB9ASMN1; SMN2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003806-B2 | Integrin antagonists useful as anticancer agents | OSI Pharmaceuticals, LLC (US) | 2011-08-23 | — | — | US | disclosed |
| US-8003806-B2 | Integrin antagonists useful as anticancer agents | OSI Pharmaceuticals, LLC (US) | 2011-08-23 | — | — | US | disclosed |
| US-8003806-B2 | Integrin antagonists useful as anticancer agents | OSI Pharmaceuticals, LLC (US) | 2011-08-23 | — | — | US | disclosed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | disclosed |