Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 4/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.33 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | GPR39 | O43194 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25118878 | 0.93 | NR1H2 (0.37) | NR1H2NR1H3PARP1TRPC3TRPC7 | |
| SCHEMBL30393384 | 0.93 | NR1H2 (0.34) | NR1H2NR1H3PARP1TRPC3TRPC7 | |
| SCHEMBL30393404 | 0.93 | NR1H2 (0.34) | NR1H2NR1H3PARP1TRPC3TRPC7 | |
| SCHEMBL22987689 | 0.93 | NR1H2 (0.34) | NR1H2NR1H3PARP1TRPC3TRPC7 | |
| SCHEMBL22987754 | 0.93 | NR1H2 (0.34) | NR1H2NR1H3PARP1TRPC3TRPC7 | |
| SCHEMBL22987752 | 0.93 | NR1H2 (0.34) | NR1H2NR1H3PARP1TRPC3TRPC7 | |
| SCHEMBL22987658 | 0.93 | NR1H2 (0.37) | NR1H2NR1H3PARP1TRPC3TRPC7 | |
| SCHEMBL22988171 | 0.93 | ADORA3 (0.35) | ADORA3ADORA2AADORA1PARP1TRPC3 | |
| SCHEMBL22987599 | 0.92 | TNKS (0.35) | ADORA3ADORA2AADORA1PARP1TRPC3 | |
| SCHEMBL22987521 | 0.92 | ADORA3 (0.35) | ADORA3ADORA2AADORA1PARP1TRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230113037-A1 | [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES | BAYER AKTIENGESELLSCHAFT (DE) | 2023-04-13 | — | — | US | disclosed |
| WO-2021028382-A1 | [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES | BAYER AKTIENGESELLSCHAFT (DE) | 2021-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230113037-A1 | [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES | AHR, HRH4, HRH1 | NR1H2 296/4885NR1H3 422/4885BRD4 443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.