Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.49 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14901056 | 0.88 | PARP10 (0.55) | PARP10PARP15FFAR4SLC6A2SLC6A4 | |
| SCHEMBL7034688 | 0.81 | SIGMAR1 (0.45) | — | |
| SCHEMBL9223677 | 0.81 | PARP10 (0.49) | PARP10PARP15FFAR4SLC6A2SLC6A4 | |
| SCHEMBL9223680 | 0.81 | PARP10 (0.49) | PARP10PARP15FFAR4SLC6A2SLC6A4 | |
| SCHEMBL9489146 | 0.79 | PARP10 (0.48) | PARP10PARP15FFAR4KDM1ASCN9A | |
| SCHEMBL9227652 | 0.78 | PARP10 (0.47) | PARP10PARP15FFAR4SLC6A2SLC6A4 | |
| SCHEMBL7760369 | 0.78 | PARP10 (0.47) | PARP10PARP15FFAR4SLC6A2SLC6A4 | |
| SCHEMBL9227647 | 0.78 | PARP10 (0.47) | PARP10PARP15FFAR4SLC6A2SLC6A4 | |
| SCHEMBL9226447 | 0.77 | PARP10 (0.46) | PARP10PARP15FFAR4SLC6A2SLC6A4 | |
| SCHEMBL15181001 | 0.77 | PARP10 (0.46) | PARP10PARP15FFAR4SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |