Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.41 |
| ▸ | JAK2 | O60674 | 17/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346150 | 0.86 | JAK1 (0.43) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL25270241 | 0.78 | MEN1 (0.45) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL9921830 | 0.78 | MEN1 (0.44) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL26148291 | 0.77 | MEN1 (0.43) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL22990017 | 0.76 | USP2 (0.41) | ALDH1A1MAPTCTSK | |
| SCHEMBL22989493 | 0.76 | JAK1 (0.45) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL23009133 | 0.74 | JAK1 (0.43) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL9918818 | 0.74 | MEN1 (0.41) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL24584618 | 0.74 | JAK1 (0.43) | JAK1JAK2MEN1ALDH1A1MAPT | |
| SCHEMBL24264915 | 0.73 | JAK1 (0.44) | JAK1JAK2MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021027943-A1 | PYRIMIDINOPYRIDAZINONE DERIVATIVE AND MEDICAL USE THEREOF | 正大天晴药业集团南京顺欣制药有限公司 | 2021-02-18 | — | — | WO | disclosed |