Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22989452 | 0.82 | NR1H2 (0.49) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL17910144 | 0.81 | NR1H2 (0.46) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL18780593 | 0.80 | USP30 (0.47) | DDB1CRBNUSP30MEN1ALDH1A1 | |
| SCHEMBL29655421 | 0.79 | NR1H2 (0.50) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL24161826 | 0.79 | NR1H2 (0.51) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL30778427 | 0.74 | NR1H2 (0.44) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL12805841 | 0.74 | GPR119 (0.41) | HPGDRECQLEPHX1GPR119 | |
| SCHEMBL14805523 | 0.74 | NR1H2 (0.47) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL3563885 | 0.73 | DDB1 (0.52) | NR1H2DDB1CRBNUSP2SMN1; SMN2 | |
| SCHEMBL21494393 | 0.72 | NR1H2 (0.46) | NR1H2DDB1CRBNUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021027943-A1 | PYRIMIDINOPYRIDAZINONE DERIVATIVE AND MEDICAL USE THEREOF | 正大天晴药业集团南京顺欣制药有限公司 | 2021-02-18 | — | — | WO | disclosed |