Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 13/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22990530 | 1.00 | ATF4 (0.54) | ATF4PRMT5WDR77EPHX2NPSR1 | |
| SCHEMBL23624612 | 0.94 | ATF4 (0.50) | ATF4PRMT5WDR77EPHX2 | |
| SCHEMBL23624616 | 0.94 | ATF4 (0.50) | ATF4PRMT5WDR77EPHX2 | |
| SCHEMBL23624517 | 0.94 | ATF4 (0.50) | ATF4PRMT5WDR77EPHX2 | |
| SCHEMBL23624519 | 0.94 | ATF4 (0.50) | ATF4PRMT5WDR77EPHX2 | |
| SCHEMBL20998373 | 0.91 | ATF4 (0.47) | ATF4PRMT5WDR77EPHX2 | |
| SCHEMBL20998423 | 0.89 | ATF4 (0.46) | ATF4PRMT5WDR77EPHX2 | |
| SCHEMBL23624622 | 0.88 | ATF4 (0.48) | ATF4PRMT5WDR77EPHX2NPSR1 | |
| SCHEMBL22627552 | 0.83 | ATF4 (0.55) | ATF4PRMT5WDR77EPHX2NPSR1 | |
| SCHEMBL23624525 | 0.83 | ATF4 (0.44) | ATF4PRMT5WDR77EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778575-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2021-02-17 | — | — | EP | disclosed |