Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | PNMT | P11086 | 6/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302227 | 0.93 | PNMT (0.51) | DRD2DRD3PNMTKDM1ATRPA1 | |
| SCHEMBL586096 | 0.84 | PNMT (0.48) | DRD2DRD3PNMTKDM1ATRPA1 | |
| SCHEMBL29618357 | 0.74 | PNMT (0.60) | DRD2DRD3PNMTKDM1ACYP11B1 | |
| SCHEMBL29741121 | 0.74 | PNMT (0.60) | DRD2DRD3PNMTKDM1ACYP11B1 | |
| SCHEMBL8222195 | 0.74 | PNMT (0.60) | DRD2DRD3PNMTKDM1ACYP11B1 | |
| SCHEMBL3363261 | 0.74 | PNMT (0.60) | DRD2DRD3PNMTKDM1ACYP11B1 | |
| Hydrochloric Acid SCHEMBL30894888 | 0.72 | PNMT (0.58) | DRD2DRD3PNMTKDM1ACYP11B1 | |
| Hydrochloric Acid SCHEMBL15205820 | 0.72 | PNMT (0.58) | DRD2DRD3PNMTKDM1ACYP11B1 | |
| SCHEMBL17350029 | 0.72 | PNMT (0.58) | DRD2DRD3PNMTKDM1ACYP11B1 | |
| SCHEMBL7647780 | 0.72 | PNMT (0.44) | DRD2DRD3PNMTKDM1ATRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |