Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22993281 | 1.00 | MCL1 (0.74) | MCL1BCL2L11 | |
| SCHEMBL29436725 | 0.93 | MCL1 (0.70) | MCL1BCL2L11 | |
| SCHEMBL29436641 | 0.93 | MCL1 (0.70) | MCL1BCL2L11 | |
| SCHEMBL22992852 | 0.92 | MCL1 (0.69) | MCL1BCL2L11 | |
| SCHEMBL29436419 | 0.92 | MCL1 (0.69) | MCL1BCL2L11 | |
| SCHEMBL22992853 | 0.92 | MCL1 (0.69) | MCL1BCL2L11 | |
| SCHEMBL29436540 | 0.92 | MCL1 (0.69) | MCL1BCL2L11 | |
| SCHEMBL22975862 | 0.92 | MCL1 (0.82) | MCL1BCL2L11 | |
| SCHEMBL22975773 | 0.92 | MCL1 (0.82) | MCL1BCL2L11 | |
| SCHEMBL22975772 | 0.92 | MCL1 (0.82) | MCL1BCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210047344-A1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | AMGEN INC. (US) | 2021-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210047344-A1 | ALPHA-HYDROXY PHENYLACETIC ACID PHARMACOPHORE OR BIOISOSTERE MCL-1 PROTEIN ANTAGONISTS | MCL1, BCL2A1, BCLAF1 | MCL1 1/4885BCL2L11 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.