Sugi Predict

Sugi Predict / Compounds / SCHEMBL2299333

SCHEMBL2299333

SCHEMBL2299333

O=C1NCCN1c1ccc(S(=O)(=O)Oc2cccc(F)c2)cc1

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ CYP1A1 P04798 8/20 0.44
▸ KDM4E B2RXH2 1/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ PTGS2 P35354 1/20 0.40
▸ P2RY2 P41231 1/20 0.40
▸ GPR17 Q13304 1/20 0.40
▸ NPC1 O15118 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ GRM5 P41594 1/20 0.38
▸ SCN9A Q15858 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2238535 0.95 CYP1A1 (0.42) ALDH1A1SMN1; SMN2CYP1A1KDM4EMEN1
SCHEMBL2299605 0.88 CYP1A1 (0.43) ALDH1A1SMN1; SMN2CYP1A1SCN9A
SCHEMBL2301973 0.88 ALDH1A1 (0.45) ALDH1A1SMN1; SMN2CYP1A1KDM4EMEN1
SCHEMBL12353905 0.86 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2CYP1A1KDM4EMEN1
SCHEMBL2304868 0.86 CYP1A1 (0.59) ALDH1A1SMN1; SMN2CYP1A1KDM4EMEN1
SCHEMBL2302674 0.86 CYP1A1 (0.59) ALDH1A1SMN1; SMN2CYP1A1KDM4EMEN1
SCHEMBL2300655 0.86 CYP1A1 (0.50) ALDH1A1SMN1; SMN2CYP1A1MAPTKMT2A
SCHEMBL2303929 0.85 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2CYP1A1KDM4EMEN1
SCHEMBL14238624 0.85 ALDH1A1 (0.43) ALDH1A1SMN1; SMN2CYP1A1KDM4EMEN1
SCHEMBL2299700 0.85 CYP1A1 (0.43) ALDH1A1SMN1; SMN2CYP1A1PTGS2SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9034888-B2 Substituted 2-imidazolidones and analogs UNIVERSITE LAVAL (CA) 2015-05-19 — — US disclosed
US-9034888-B2 Substituted 2-imidazolidones and analogs UNIVERSITE LAVAL (CA) 2015-05-19 — — US disclosed
US-9034888-B2 Substituted 2-imidazolidones and analogs UNIVERSITE LAVAL (CA) 2015-05-19 — — US disclosed
EP-2536693-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS Université Laval (CA) 2012-12-26 — — EP disclosed
US-20120309777-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS UNIVERSITE LAVAL (CA) 2012-12-06 — — US disclosed
US-20120309777-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS UNIVERSITE LAVAL (CA) 2012-12-06 — — US disclosed
US-20120309777-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS UNIVERSITE LAVAL (CA) 2012-12-06 — — US disclosed
WO-2011100840-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS UNIVERSITé LAVAL (CA) 2011-08-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120309777-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS CCNY, RPS4Y1, TPX2 ALDH1A1 1937/4885SMN1; SMN2 2479/4885CYP1A1 1777/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.