Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 4/20 | 0.52 |
| ▸ | CCNH | P51946 | 4/20 | 0.52 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.52 |
| ▸ | CCNK | O75909 | 4/20 | 0.52 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.52 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | CDK2 | P24941 | 8/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.45 |
| ▸ | JUN | P05412 | 5/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17385160 | 0.85 | NR4A2 (0.54) | NR4A2CREBBPCDK7CCNHMNAT1 | |
| SCHEMBL12627364 | 0.79 | JAK2 (0.65) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL22994878 | 0.79 | EGFR (0.52) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL19054611 | 0.78 | CDK7 (0.64) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL21549451 | 0.78 | JAK2 (0.49) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL17384789 | 0.75 | EGFR (0.52) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL20416024 | 0.75 | CDK7 (0.64) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL21549440 | 0.75 | CDK7 (0.57) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL20416390 | 0.74 | CDK7 (0.66) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL22994862 | 0.74 | EGFR (0.54) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778584-A1 | PRODUCTION PROCESS OF 2-CHLORO-4-HETEROARYL-PYRIMIDINE DERIVATIVES | ARIAD Pharmaceuticals, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |