Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
| ▸ | CCNH | P51946 | 2/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17384789 | 0.91 | EGFR (0.52) | EGFRIGF1RKCNH2ALKFLT3 | |
| SCHEMBL22994862 | 0.89 | EGFR (0.54) | EGFRIGF1RKCNH2ALKFLT3 | |
| SCHEMBL22510163 | 0.88 | EGFR (0.52) | EGFRIGF1RKCNH2CDK2 | |
| SCHEMBL17384788 | 0.85 | EGFR (0.62) | EGFRIGF1RKCNH2 | |
| SCHEMBL22510212 | 0.85 | EGFR (0.47) | EGFRIGF1RKCNH2ALKCDK2 | |
| SCHEMBL22994874 | 0.84 | EGFR (0.57) | EGFRIGF1RKCNH2ALKPLK1 | |
| SCHEMBL22510191 | 0.84 | EGFR (0.49) | EGFRIGF1RKCNH2ALKFLT3 | |
| SCHEMBL22510201 | 0.83 | EGFR (0.51) | EGFRIGF1RKCNH2FLT3MKNK1 | |
| SCHEMBL22994856 | 0.82 | EGFR (0.52) | EGFRIGF1RKCNH2 | |
| SCHEMBL22994852 | 0.80 | EGFR (0.62) | EGFRIGF1RKCNH2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778584-A1 | PRODUCTION PROCESS OF 2-CHLORO-4-HETEROARYL-PYRIMIDINE DERIVATIVES | ARIAD Pharmaceuticals, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |