Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22510270 | 0.86 | EGFR (0.77) | EGFRKCNH2IGF1R | |
| SCHEMBL17384930 | 0.86 | EGFR (0.75) | EGFRKCNH2IGF1R | |
| SCHEMBL22994862 | 0.86 | EGFR (0.54) | EGFRKCNH2IGF1RALKPLK1 | |
| SCHEMBL17384788 | 0.85 | EGFR (0.62) | EGFRKCNH2IGF1R | |
| SCHEMBL22510163 | 0.85 | EGFR (0.52) | EGFRKCNH2IGF1R | |
| SCHEMBL22994878 | 0.84 | EGFR (0.52) | EGFRKCNH2IGF1RALKPLK1 | |
| SCHEMBL17384789 | 0.84 | EGFR (0.52) | EGFRKCNH2IGF1RALK | |
| SCHEMBL22510201 | 0.81 | EGFR (0.51) | EGFRKCNH2IGF1R | |
| SCHEMBL22510191 | 0.80 | EGFR (0.49) | EGFRKCNH2IGF1RALK | |
| SCHEMBL17373135 | 0.80 | EGFR (0.59) | EGFRKCNH2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778584-A1 | PRODUCTION PROCESS OF 2-CHLORO-4-HETEROARYL-PYRIMIDINE DERIVATIVES | ARIAD Pharmaceuticals, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |