Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 4/20 | 0.48 |
| ▸ | BCR | P11274 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | ILK | Q13418 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 5/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25337284 | 0.84 | GAA (0.45) | GAAPDPK1ABL1BCRKDR | |
| SCHEMBL1394029 | 0.83 | MAPT (0.49) | GAAALDH1A1MAPTGFERKDM4E | |
| SCHEMBL1135530 | 0.82 | KDM4E (0.48) | GAAALDH1A1MAPTGFERKDM4E | |
| SCHEMBL19208648 | 0.82 | KDM4E (0.48) | GAAALDH1A1MAPTGFERPDPK1 | |
| SCHEMBL30424394 | 0.82 | KDM4E (0.48) | GAAALDH1A1MAPTGFERKDM4E | |
| SCHEMBL2019158 | 0.81 | GAA (0.54) | GAAPDPK1ABL1BCRKDM4E | |
| SCHEMBL700007 | 0.81 | KDM4E (0.47) | GAAALDH1A1MAPTGFERKDM4E | |
| SCHEMBL6131697 | 0.79 | KDM4E (0.46) | GAAALDH1A1MAPTKDM4ESTAT3 | |
| SCHEMBL1957824 | 0.78 | KDR (0.47) | ABL1BCRKDRKITFLT3 | |
| SCHEMBL28791345 | 0.77 | KDM4E (0.43) | GAAALDH1A1MAPTGFERKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021027503-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND INTERMEDIATE AND USE THEREOF | 罗欣药业(上海)有限公司 | 2021-02-18 | — | — | WO | disclosed |
| WO-2021027503-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND INTERMEDIATE AND USE THEREOF | 罗欣药业(上海)有限公司 | 2021-02-18 | — | — | WO | disclosed |