Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1394029 | 0.81 | MAPT (0.49) | KDM4ESTAT3HIF1ARIPK1NR4A2 | |
| SCHEMBL1135530 | 0.79 | KDM4E (0.48) | KDM4ESTAT3HIF1ARIPK1NR4A2 | |
| SCHEMBL22996547 | 0.79 | GAA (0.50) | KDM4ESTAT3HIF1ANR4A2TSHR | |
| SCHEMBL19208648 | 0.79 | KDM4E (0.48) | KDM4ESTAT3HIF1ARIPK1NR4A2 | |
| SCHEMBL30424394 | 0.79 | KDM4E (0.48) | KDM4ESTAT3HIF1ARIPK1NR4A2 | |
| SCHEMBL700007 | 0.78 | KDM4E (0.47) | KDM4ESTAT3HIF1ARIPK1NR4A2 | |
| SCHEMBL28791345 | 0.75 | KDM4E (0.43) | KDM4ESTAT3HIF1ARIPK1NR4A2 | |
| SCHEMBL1080836 | 0.75 | KDM4E (0.37) | KDM4ESTAT3HIF1ALMNAALDH1A1 | |
| SCHEMBL2899661 | 0.75 | KDM4E (0.38) | KDM4EHIF1AGABRA1GABRB2LMNA | |
| SCHEMBL1672317 | 0.74 | KDM4E (0.49) | KDM4ESTAT3HIF1ARIPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534286-A1 | METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISEASES WITH 2,4-PYRIMIDINEDIAMINE COMPOUNDS | Rigel Pharmaceuticals, Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004014382-A1 | METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISEASES WITH 2,4-PYRIMIDINEDIAMINE COMPOUNDS | RIGEL PHARMACEUTICALS (US) | 2004-02-19 | — | — | WO | disclosed |