SCHEMBL22997666 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	CCNE1	P24864	17/20	0.37

▸	CDK2	P24941	17/20	0.37

▸	CCND1	P24385	13/20	0.37

▸	CDK6	Q00534	13/20	0.37

▸	CDK4	P11802	9/20	0.37

▸	CCND3	P30281	9/20	0.37

▸	CDK1	P06493	8/20	0.37

▸	CCNB1	P14635	8/20	0.37

▸	CCNT1	O60563	6/20	0.37

▸	CDK9	P50750	6/20	0.37

▸	CDK7	P50613	6/20	0.37

▸	CCNH	P51946	6/20	0.37

▸	MNAT1	P51948	6/20	0.37

▸	CCNK	O75909	3/20	0.32

▸	CDK12	Q9NYV4	3/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL22997633	0.90	CCNE1 (0.45)	CCNE1CDK2CCND1CDK6CDK4
SCHEMBL22977315	0.88	CCNE1 (0.47)	CCNE1CDK2CCND1CDK6CDK4
SCHEMBL23001272	0.86	CCNE1 (0.40)	CCNE1CDK2CCND1CDK6CDK4
SCHEMBL22997683	0.85	CCNE1 (0.40)	CCNE1CDK2CCND1CDK6CDK4
SCHEMBL22997855	0.83	CCNE1 (0.39)	CCNE1CDK2CCND1CDK6CDK4
SCHEMBL22997761	0.83	CCNE1 (0.39)	CCNE1CDK2CCND1CDK6CDK4
SCHEMBL22997732	0.81	CCNE1 (0.37)	CCNE1CDK2CCND1CDK6CDK4
SCHEMBL22997687	0.81	CCNE1 (0.47)	CCNE1CDK2CCND1CDK6CDK4
SCHEMBL23001282	0.81	CDK7 (0.39)	CCNE1CDK2CCND1CDK6CDK4
SCHEMBL22977352	0.80	CCNE1 (0.58)	CCNE1CDK2CCND1CDK6CDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2021030537-A1	IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS	INCYTE CORPORATION (US)	2021-02-18	—	—	WO	disclosed