Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 14/20 | 0.40 |
| ▸ | CDK2 | P24941 | 14/20 | 0.40 |
| ▸ | CCND1 | P24385 | 11/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 11/20 | 0.40 |
| ▸ | CDK4 | P11802 | 7/20 | 0.40 |
| ▸ | CCND3 | P30281 | 7/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.40 |
| ▸ | CDK9 | P50750 | 6/20 | 0.40 |
| ▸ | CDK1 | P06493 | 5/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.40 |
| ▸ | CDK7 | P50613 | 4/20 | 0.40 |
| ▸ | CCNH | P51946 | 4/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.40 |
| ▸ | CCNK | O75909 | 3/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22997873 | 0.90 | CCNE1 (0.47) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL23001272 | 0.90 | CCNE1 (0.40) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22997880 | 0.89 | CCNE1 (0.47) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL29821169 | 0.88 | CCNE1 (0.51) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL30449178 | 0.88 | CCNE1 (0.51) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22976999 | 0.88 | CCNE1 (0.51) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22977146 | 0.88 | CCNE1 (0.51) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22997666 | 0.85 | CCNE1 (0.37) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22997677 | 0.84 | CCNE1 (0.46) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL22997871 | 0.84 | CCNE1 (0.46) | CCNE1CDK2CCND1CDK6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021030537-A1 | IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION (US) | 2021-02-18 | — | — | WO | disclosed |