Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 12/20 | 0.49 |
| ▸ | RAB9A | P51151 | 12/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2299134 | 0.93 | NPC1 (0.49) | SMN1; SMN2HPGDNPC1RAB9AKCNK9 | |
| SCHEMBL5300999 | 0.91 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDNPC1RAB9AAKR1C3 | |
| SCHEMBL2295674 | 0.90 | NPC1 (0.56) | SMN1; SMN2HPGDNPC1RAB9ATP53 | |
| SCHEMBL2296039 | 0.90 | NPC1 (0.52) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL2294968 | 0.90 | NPC1 (0.59) | SMN1; SMN2HPGDNPC1RAB9ATP53 | |
| SCHEMBL5298078 | 0.89 | NPC1 (0.48) | SMN1; SMN2NPC1RAB9ATP53MEN1 | |
| SCHEMBL2294143 | 0.89 | NPC1 (0.53) | SMN1; SMN2HPGDNPC1RAB9ATP53 | |
| SCHEMBL2296016 | 0.89 | NPC1 (0.50) | SMN1; SMN2HPGDNPC1RAB9ATP53 | |
| SCHEMBL2292563 | 0.88 | RAB9A (0.50) | SMN1; SMN2NPC1RAB9ATP53MAPT | |
| SCHEMBL2298233 | 0.88 | NPC1 (0.55) | SMN1; SMN2NPC1RAB9AKCNK9TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003806-B2 | Integrin antagonists useful as anticancer agents | OSI Pharmaceuticals, LLC (US) | 2011-08-23 | — | — | US | claimed |
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| US-20060116383-A1 | Integrin antagonists useful as anticancer agents | ALCATEL LUCENT (FR) | 2006-06-01 | — | — | US | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116383-A1 | Integrin antagonists useful as anticancer agents | ITGB5, ITGA5, ITGB1 | SMN1; SMN2 2159/4885HPGD 2856/4885NPC1 2770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.