Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 15/20 | 0.53 |
| ▸ | CDK12 | Q9NYV4 | 15/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 14/20 | 0.53 |
| ▸ | CDK9 | P50750 | 14/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 12/20 | 0.53 |
| ▸ | CDK2 | P24941 | 12/20 | 0.53 |
| ▸ | CDK7 | P50613 | 10/20 | 0.53 |
| ▸ | CCNH | P51946 | 10/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 10/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22977406 | 1.00 | CCNK (0.53) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL22977457 | 0.89 | CCNK (0.48) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL22997812 | 0.89 | CCNK (0.48) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL22977485 | 0.83 | ULK1 (0.47) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL31666811 | 0.81 | CCNK (0.61) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL31666705 | 0.81 | CCNK (0.61) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL22997838 | 0.80 | CCNE1 (0.41) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL22977388 | 0.78 | CCNE1 (0.40) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL22977318 | 0.78 | CCNE1 (0.54) | CCNE1CDK2CDK7CCNHMNAT1 | |
| SCHEMBL22997740 | 0.78 | CCNK (0.46) | CCNKCDK12CCNT1CDK9CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021030537-A1 | IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION (US) | 2021-02-18 | — | — | WO | disclosed |