⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2293759 | 0.82 | — | — | |
| SCHEMBL7978095 | 0.78 | — | — | |
| SCHEMBL4432277 | 0.78 | — | — | |
| SCHEMBL9385886 | 0.76 | — | — | |
| SCHEMBL629483 | 0.74 | — | — | |
| SCHEMBL7593962 | 0.68 | — | — | |
| SCHEMBL10959286 | 0.68 | ALDH1A1 (0.33) | — | |
| SCHEMBL408353 | 0.67 | — | — | |
| SCHEMBL3432605 | 0.66 | TSHR (0.37) | — | |
| SCHEMBL11758549 | 0.66 | GRIN2D (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481517-B2 | Pyrrolidine compounds,pharmaceutical compositions containing the same, devices containing the same, and methods of treating asthma or chronic obstructive pulmonary disease by administering the same | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-07-09 | — | — | US | disclosed |
| EP-2531516-A2 | PREGNANE COMPOUNDS CONDENSED IN POSITION 16,17 WITH A PYROLIDINE RING WITH GLUCOCORTICOID ACTIVITY | Chiesi Farmaceutici S.p.A. (IT) | 2012-12-12 | — | — | EP | disclosed |
| US-20110201580-A1 | PYRROLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-08-18 | — | — | US | disclosed |
| WO-2011095535-A2 | PYRROLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-08-11 | — | — | WO | disclosed |