Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | GRK6 | P43250 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 3/20 | 0.42 |
| ▸ | CHUK | O15111 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL631299 | 0.98 | CYP3A4 (0.52) | CYP3A4GRK6ALDH1A1KDM4EGLA | |
| SCHEMBL29791639 | 0.83 | ALDH1A1 (0.59) | CYP3A4GRK6ALDH1A1KDM4EGLA | |
| SCHEMBL5886297 | 0.83 | CYP3A4 (0.70) | CYP3A4ALDH1A1KDM4EGLAGAA | |
| SCHEMBL1807629 | 0.83 | ALDH1A1 (0.59) | CYP3A4GRK6ALDH1A1KDM4EGLA | |
| Hydrochloric Acid SCHEMBL11794608 | 0.81 | CYP3A4 (0.68) | CYP3A4ALDH1A1KDM4EGLAGAA | |
| SCHEMBL3660474 | 0.81 | CYP3A4 (0.52) | CYP3A4GRK6ALDH1A1KDM4EGLA | |
| SCHEMBL23293839 | 0.79 | IKBKB (0.42) | CYP3A4GRK6ALDH1A1KDM4EGLA | |
| SCHEMBL19646057 | 0.79 | KDM4E (0.46) | CYP3A4GRK6ALDH1A1KDM4EGLA | |
| SCHEMBL1632314 | 0.79 | CYP3A4 (0.41) | CYP3A4GRK6ALDH1A1KDM4EGLA | |
| SCHEMBL29373932 | 0.79 | KDM4E (0.46) | CYP3A4GRK6ALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102884054-B | Fluoroalkyl-substituted 2-amidobenzimidazoles and the use thereof for boosting stress tolerance in plants | BAYER IP GMBH | 2015-01-14 | — | — | CN | disclosed |
| US-20140296235-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBVIE INC. | 2014-10-02 | — | — | US | disclosed |
| EP-2542533-B1 | FLUORALKYL-SUBSTITUTED 2-AMIDOBENZIMIDAZOLES AND THEIR USE FOR INCREASING STRESS TOLERANCE IN PLANTS | BAYER IP GMBH (DE) | 2014-09-10 | — | — | EP | disclosed |
| US-8697736-B2 | 1H-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent PARP inhibitors | ABBVIE INC. (US) | 2014-04-15 | — | — | US | disclosed |
| CN-101511821-B | Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors | ABBOTT LAB | 2013-07-17 | — | — | CN | disclosed |
| EP-2561759-A1 | Fluoroalkyl-substituted 2-amidobenzimidazoles and their effect on plant growth | Bayer Cropscience AG (DE) | 2013-02-27 | — | — | EP | disclosed |
| CN-102884054-A | Fluoroalkyl-substituted 2-amidobenzimidazoles and the use thereof for boosting stress tolerance in plants | BAYER IP GMBH | 2013-01-16 | — | — | CN | disclosed |
| EP-2542533-A1 | FLUOROALKYL-SUBSTITUTED 2-AMIDOBENZIMIDAZOLES AND THE USE THEREOF FOR BOOSTING STRESS TOLERANCE IN PLANTS | Bayer Intellectual Property GmbH (DE) | 2013-01-09 | — | — | EP | disclosed |
| US-8217070-B2 | 2-substituted-1H-benzimidazole-4-carboxamides are PARP inhibitors | ABBOTT LABORATORIES (US) | 2012-07-10 | — | — | US | disclosed |
| WO-2012038751-A3 | PROCESS FOR THE PURIFICATION OF AROMATIC DICARBOXYLIC ACID | DAVY PROCESS TECHNOLOGY LIMITED (GB) | 2012-05-10 | — | — | WO | disclosed |
| EP-1957477-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2008-08-20 | — | — | EP | disclosed |
| US-20070270476-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | ABBVIE INC. | 2007-11-22 | — | — | US | disclosed |
| WO-2007131016-A2 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2007-11-15 | — | — | WO | disclosed |
| US-20070259937-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES | 2007-11-08 | — | — | US | disclosed |
| US-20070179136-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBVIE INC. | 2007-08-02 | — | — | US | disclosed |
| WO-2007059230-A2 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2007-05-24 | — | — | WO | disclosed |
| US-20070112047-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | ABBVIE INC. | 2007-05-17 | — | — | US | disclosed |
| WO-2007041357-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2006110683-A1 | 2-SUBSTITUTED-1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2006-10-19 | — | — | WO | disclosed |
| US-20060229351-A1 | 2-Substituted-1 H-benzimidazile-4-carboxamides are PARP inhibitors | ABBVIE INC. | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259937-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | CYP3A4 384/4885GRK6 3753/4885ALDH1A1 323/4885 |
| US-20060229351-A1 | 2-Substituted-1 H-benzimidazile-4-carboxamides are PARP inhibitors | PARP1, PARP2, PARP4 | CYP3A4 1220/4885GRK6 3512/4885ALDH1A1 233/4885 |
| US-20070112047-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | CYP3A4 1185/4885GRK6 3457/4885ALDH1A1 239/4885 |
| US-20140296235-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | CYP3A4 821/4885GRK6 3555/4885ALDH1A1 193/4885 |
| US-20070179136-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | CYP3A4 854/4885GRK6 3498/4885ALDH1A1 199/4885 |
| US-20070270476-A1 | SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | CYP3A4 1185/4885GRK6 3457/4885ALDH1A1 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.