Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 15/20 | 0.62 |
| ▸ | DAGLB | Q8NCG7 | 4/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | SPPL2A | Q8TCT8 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300879 | 0.83 | DAGLA (0.73) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2299392 | 0.83 | DAGLA (0.65) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27904898 | 0.79 | DAGLA (0.61) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2299871 | 0.77 | DAGLA (1.00) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2298832 | 0.74 | DAGLA (0.70) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27888096 | 0.73 | DAGLA (0.63) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2299545 | 0.70 | DAGLA (0.69) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2343368 | 0.70 | DAGLA (1.00) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2302253 | 0.69 | DAGLA (0.88) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27904880 | 0.69 | DAGLA (0.71) | DAGLADAGLBCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536694-A1 | GLYCINE SULFONAMIDES FOR USE AS INHIBITORS OF DIACYLGLYCEROL LIPASE | Bristol-Myers Squibb Company (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103055-A1 | GLYCINE SULFONAMIDES FOR USE AS INHIBITORS OF DIACYLGLYCEROL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-08-25 | — | — | WO | disclosed |