Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.51 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | STK25 | O00506 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | MUSK | O15146 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1083288 | 0.76 | SYK (0.62) | SYKADORA3TYRO3BMPR1BCDC7 | |
| SCHEMBL12854262 | 0.76 | SYK (0.69) | SYKADORA3TYRO3BMPR1BCDC7 | |
| SCHEMBL22068257 | 0.76 | SYK (0.69) | SYKADORA3TYRO3BMPR1BCDC7 | |
| SCHEMBL14235384 | 0.76 | SYK (0.49) | SYKADORA3TYRO3BMPR1BCDC7 | |
| SCHEMBL12212784 | 0.73 | SYK (0.66) | SYKADORA3TYRO3BMPR1BCDC7 | |
| SCHEMBL12237025 | 0.73 | SYK (0.66) | SYKADORA3TYRO3BMPR1BCDC7 | |
| SCHEMBL14213425 | 0.72 | SYK (0.47) | SYKADORA3TYRO3BMPR1BCDC7 | |
| SCHEMBL2627048 | 0.72 | SYK (0.72) | SYKADORA3TYRO3BMPR1BCDC7 | |
| SCHEMBL2523179 | 0.71 | SYK (0.70) | SYKADORA3TYRO3BMPR1BCDC7 | |
| SCHEMBL16606964 | 0.70 | SYK (0.52) | SYKADORA3TYRO3BMPR1BCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4013420-B1 | METHOD OF BLOCKING OR AMELIORATING CYTOKINE RELEASE SYNDROME | RIGEL PHARMACEUTICALS INC (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2021030526-A1 | METHOD OF BLOCKING OR AMELIORATING CYTOKINE RELEASE SYNDROME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-02-18 | — | — | WO | disclosed |