Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.42 |
| ▸ | HTR1A | P08908 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300974 | 0.85 | SLC6A4 (0.54) | SLC6A2SLC6A4SLC6A3HTR1ASMN1; SMN2 | |
| SCHEMBL3129196 | 0.82 | SLC6A4 (0.41) | SLC6A2SLC6A4SLC6A3HTR1AALDH1A1 | |
| SCHEMBL2301991 | 0.79 | HTR1A (0.41) | SLC6A2SLC6A4SLC6A3HTR1AKCNH2 | |
| SCHEMBL14957210 | 0.78 | SLC6A2 (0.64) | SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL9913885 | 0.76 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3HTR1AALDH1A1 | |
| SCHEMBL9913817 | 0.76 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3HTR1AALDH1A1 | |
| SCHEMBL15477138 | 0.76 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3HTR1AALDH1A1 | |
| SCHEMBL3080032 | 0.75 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3HTR1AKCNH2 | |
| Hydrochloric Acid SCHEMBL9275471 | 0.75 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3HTR1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL9275475 | 0.75 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3HTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536689-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | Amgen Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011103196-A1 | ARYL CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL INHIBITORS FOR TREATMENT OF PAIN | AMGEN INC. (US) | 2011-08-25 | — | — | WO | disclosed |