Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29587235 | 0.75 | KDM4E (0.61) | JMJD6PROKR1MAPTKCNK3KCNK9 | |
| SCHEMBL17761 | 0.75 | KDM4E (0.61) | JMJD6PROKR1MAPTKCNK3KCNK9 | |
| SCHEMBL17559434 | 0.74 | IKBKE (0.51) | LRRK2MAPTEGLN1PIK3CAPDE4D | |
| SCHEMBL28560721 | 0.73 | ATXN2 (0.41) | JMJD6PIK3CA | |
| SCHEMBL30533369 | 0.73 | PROKR1 (0.50) | PROKR1KCNK3KCNK9PDE4DPDE4B | |
| SCHEMBL16319004 | 0.73 | PROKR1 (0.50) | PROKR1KCNK3KCNK9PDE4DPDE4B | |
| SCHEMBL27841468 | 0.71 | KCNK3 (0.52) | PROKR1KCNK3KCNK9 | |
| SCHEMBL29210003 | 0.71 | TLR9 (0.46) | LRRK2PROKR1 | |
| SCHEMBL5185766 | 0.70 | KMT2A (0.59) | MAPT | |
| SCHEMBL30755291 | 0.70 | KDM4E (0.51) | JMJD6LRRK2PIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032148-A1 | AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-02-25 | — | — | WO | disclosed |