Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | CDC7 | O00311 | 9/20 | 0.49 |
| ▸ | DBF4 | Q9UBU7 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31149180 | 1.00 | CASP1 (0.59) | CASP1MAPK1MAPTNPSR1RXFP1 | |
| SCHEMBL30831836 | 0.86 | CYP1A2 (0.51) | MAPK1MAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL5642066 | 0.82 | CYP1A2 (0.64) | MAPTALDH1A1HSD17B10CYP1A2KMT2A | |
| SCHEMBL31149187 | 0.78 | CYP1A2 (0.43) | CASP1MAPTCDC7DBF4ALDH1A1 | |
| SCHEMBL23015323 | 0.78 | CYP1A2 (0.43) | CASP1MAPTCDC7DBF4ALDH1A1 | |
| SCHEMBL5549764 | 0.77 | CDC7 (0.53) | CASP1MAPK1MAPTCDC7DBF4 | |
| SCHEMBL5899800 | 0.75 | CASP1 (0.74) | CASP1MAPK1MAPTNPSR1RXFP1 | |
| SCHEMBL13197220 | 0.75 | CYP1A2 (0.56) | MAPTALDH1A1HSD17B10CYP1A2KMT2A | |
| SCHEMBL29524945 | 0.75 | CYP1A2 (0.56) | MAPTALDH1A1HSD17B10CYP1A2KMT2A | |
| SCHEMBL1645260 | 0.75 | CYP1A2 (0.56) | MAPTNPSR1ALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220288065-A1 | MONOCYCLIC AGONISTS OF STIMULATOR OF INTERFERON GENES STING | THE SCRIPPS RESEARCH INSTITUTE | 2022-09-15 | — | — | US | disclosed |
| CN-114981256-A | Single-ring agonists of the interferon gene stimulator STING | 斯克里普斯研究学院 | 2022-08-30 | — | — | CN | disclosed |
| EP-4017592-A1 | MONOCYCLIC AGONISTS OF STIMULATOR OF INTERFERON GENES STING | The Scripps Research Institute (US) | 2022-06-29 | — | — | EP | disclosed |
| WO-2021035257-A1 | MONOCYCLIC AGONISTS OF STIMULATOR OF INTERFERON GENES STING | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220288065-A1 | MONOCYCLIC AGONISTS OF STIMULATOR OF INTERFERON GENES STING | STING1, IRF3, CGAS | CASP1 403/4885MAPK1 3141/4885MAPT 4801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.