Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.45 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.44 |
| ▸ | KDM5A | P29375 | 3/20 | 0.44 |
| ▸ | KDM5C | P41229 | 2/20 | 0.44 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17920368 | 0.86 | KDM5A (0.55) | POLBCYP1A2HTTKDM4EKDM5B | |
| SCHEMBL17689113 | 0.85 | TP53 (0.54) | POLBCYP1A2HPGDKDM4EKDM5B | |
| SCHEMBL10357586 | 0.81 | HPGD (0.51) | POLBHPGDHTTKDM4ESMPD1 | |
| SCHEMBL8945334 | 0.81 | POLB (0.54) | POLBHPGDHTTKDM4ENEK1 | |
| SCHEMBL16572977 | 0.81 | CYP1A2 (0.56) | POLBCYP1A2KDM4EKDM5BKDM5A | |
| SCHEMBL2989555 | 0.81 | CYP1A2 (0.60) | POLBCYP1A2HTTKDM4EKDM5B | |
| SCHEMBL15714181 | 0.81 | CYP1A2 (0.49) | POLBCYP1A2HTTKDM4EKDM5B | |
| SCHEMBL18369044 | 0.78 | CYP1A2 (0.47) | POLBCYP1A2HPGDHTTKDM4E | |
| SCHEMBL3299192 | 0.78 | HPGD (0.51) | POLBHPGDHTTKDM4ESMPD1 | |
| SCHEMBL17804151 | 0.78 | HPGD (0.59) | POLBHPGDHTTKDM4ENEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10927106-B2 | Benzothiazole derivatives as DYRK1 inhibitors | PHARMASUM THERAPEUTICS AS (NO) | 2021-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927106-B2 | Benzothiazole derivatives as DYRK1 inhibitors | DYRK1A, DYRK1B, PDK2 | POLB 2360/4885CYP1A2 2199/4885HPGD 2051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.