Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.48 |
| ▸ | KDM5A | P29375 | 2/20 | 0.47 |
| ▸ | KDM5C | P41229 | 2/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | TET3 | O43151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9561544 | 0.89 | POLB (0.51) | POLBITGB3ITGA2BKMT2AMEN1 | |
| SCHEMBL8945361 | 0.89 | ITGB3 (0.44) | POLBHPGDHTTITGB3ITGA2B | |
| Lufironil SCHEMBL344625 | 0.84 | HPGD (0.56) | HPGDITGB3ITGA2BKMT2AMEN1 | |
| SCHEMBL3299192 | 0.83 | HPGD (0.51) | POLBHPGDHTTKMT2AMEN1 | |
| SCHEMBL10357586 | 0.83 | HPGD (0.51) | POLBHPGDHTTKMT2AMEN1 | |
| SCHEMBL17804151 | 0.83 | HPGD (0.59) | POLBHPGDHTTKMT2AMEN1 | |
| SCHEMBL4353042 | 0.83 | ITGB3 (0.47) | HTTITGB3ITGA2BKMT2AMEN1 | |
| SCHEMBL5215104 | 0.82 | KDM5B (0.71) | HTTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL5214030 | 0.82 | RAB9A (0.62) | HTTITGB3ITGA2BKMT2AMEN1 | |
| Safironil SCHEMBL344153 | 0.82 | ALDH1A1 (0.62) | HPGDHTTITGB3ITGA2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409119-B1 | N,N'-Bis(alkoxy-alkyl)-pyridine-2,4-dicarboxylic acid amides, process for their preparation as well as their use | HOECHST AG (DE) | 1994-04-13 | — | — | EP | claimed |
| JP-3058973-A | — | — | None | — | — | JP | disclosed |
| US-5519038-A | ENZYME INHIBITORS SUITABLE AS FIBROSUPPRESSANTS AND IMMUNOSUPPRESSANTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-21 | — | — | US | disclosed |
| JP-H0358973-A | N,N'-BIS(ALKOXYALKYL)-PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES | HOECHST AG | 1991-03-14 | — | — | JP | disclosed |
| EP-0409119-A1 | N,N'-Bis(alkoxy-alkyl)-pyridine-2,4-dicarboxylic acid amides, process for their preparation as well as their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-01-23 | — | — | EP | disclosed |