Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MDH2 | P40926 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16587496 | 0.87 | SMN1; SMN2 (0.46) | ALDH1A1HPGDMDH2SMN1; SMN2POLB | |
| SCHEMBL12993083 | 0.85 | ALDH1A1 (0.49) | ALDH1A1HPGDMDH2SMN1; SMN2POLB | |
| SCHEMBL16437764 | 0.80 | POLB (0.49) | ALDH1A1HPGDMDH2SMN1; SMN2POLB | |
| SCHEMBL19853588 | 0.75 | ALDH1A1 (0.49) | ALDH1A1HPGDMDH2SMN1; SMN2POLB | |
| SCHEMBL18473801 | 0.74 | KCNA5 (0.52) | ALDH1A1HPGDSMN1; SMN2POLBHTT | |
| SCHEMBL18567041 | 0.71 | SMN1; SMN2 (0.48) | ALDH1A1HPGDMDH2SMN1; SMN2POLB | |
| SCHEMBL19730907 | 0.71 | SIRT2 (0.50) | PARP10ALDH1A1HPGDSMN1; SMN2PARP1 | |
| SCHEMBL5264504 | 0.70 | MAPK14 (0.45) | ALDH1A1HPGDMDH2SMN1; SMN2POLB | |
| SCHEMBL16587510 | 0.70 | ALDH1A1 (0.47) | ALDH1A1HPGDMDH2SMN1; SMN2POLB | |
| SCHEMBL19706906 | 0.69 | MAPK14 (0.46) | ALDH1A1HPGDMDH2SMN1; SMN2GSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3456721-B1 | METHOD OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIVITORY ACTIVITY | SHIONOGI & CO (JP) | 2021-02-24 | — | — | EP | disclosed |