Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 7/20 | 0.57 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.56 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.40 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29954239 | 0.82 | ERN1 (0.55) | ERN1TRIM24TRIM33CA1CA2 | |
| SCHEMBL36440 | 0.73 | ERN1 (1.00) | ERN1TRIM24TRIM33CA1CA2 | |
| SCHEMBL29407137 | 0.73 | ERN1 (1.00) | ERN1TRIM24TRIM33CA1CA2 | |
| SCHEMBL6048616 | 0.73 | ERN1 (0.67) | ERN1TRIM24TRIM33CA1CA2 | |
| Salicyladehyde SCHEMBL29386538 | 0.72 | — | — | |
| Salicyladehyde SCHEMBL901265 | 0.72 | TRIM24 (1.00) | ERN1TRIM24TRIM33CA1CA2 | |
| Salicyladehyde SCHEMBL15395 | 0.72 | — | — | |
| SCHEMBL1302180 | 0.71 | ERN1 (0.64) | ERN1TRIM24TRIM33CA1CA2 | |
| SCHEMBL19595083 | 0.71 | ERN1 (0.57) | ERN1TRIM24TRIM33CA1CA2 | |
| Salicyladehyde SCHEMBL6917405 | 0.70 | TRIM24 (0.95) | ERN1TRIM24TRIM33CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858825-A1 | BICYCLIC-FUSED HETEROARYL COMPOUNDS AS IRAK4 MODULATORS | Pfizer Inc. (US) | 2021-08-04 | — | — | EP | disclosed |
| EP-3341367-B1 | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AS IRAK4 MODULATORS | PFIZER (US) | 2021-02-24 | — | — | EP | disclosed |