Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 12/20 | 0.63 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.45 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18124191 | 1.00 | USP30 (0.63) | USP30RIPK1PARP1IGF1RCDK1 | |
| SCHEMBL18116016 | 0.86 | CDK2 (0.49) | USP30CDK1CDK2JAK2BRD4 | |
| SCHEMBL19990920 | 0.86 | CDK2 (0.49) | USP30CDK1CDK2JAK2BRD4 | |
| SCHEMBL28513485 | 0.82 | USP30 (0.67) | USP30RIPK1PARP1HDAC4HDAC6 | |
| SCHEMBL29778997 | 0.82 | USP30 (0.67) | USP30RIPK1PARP1HDAC4HDAC6 | |
| SCHEMBL18124183 | 0.82 | USP30 (0.67) | USP30RIPK1PARP1HDAC4HDAC6 | |
| SCHEMBL18124204 | 0.81 | USP30 (0.70) | USP30RIPK1PARP1HDAC4HDAC6 | |
| SCHEMBL23019685 | 0.81 | USP30 (0.70) | USP30RIPK1PARP1HDAC4HDAC6 | |
| SCHEMBL29779090 | 0.81 | USP30 (0.70) | USP30RIPK1PARP1HDAC4HDAC6 | |
| SCHEMBL18115533 | 0.79 | USP30 (0.62) | USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3277677-B1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2021-02-24 | — | — | EP | disclosed |