Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zoledronic Acid Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 10/20 | 1.00 |
| ▸ | GGPS1 | O95749 | 3/20 | 1.00 |
| ▸ | BTN3A1 | O00481 | 1/20 | 1.00 |
| ▸ | CA12 | O43570 | 1/20 | 1.00 |
| ▸ | CA2 | P00918 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | MMP2 | P08253 | 1/20 | 1.00 |
| ▸ | MMP9 | P14780 | 1/20 | 1.00 |
| ▸ | MMP8 | P22894 | 1/20 | 1.00 |
| ▸ | MMP14 | P50281 | 1/20 | 1.00 |
| ▸ | CA9 | Q16790 | 1/20 | 1.00 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zoledronic Acid Anhydrous SCHEMBL1160625 | 1.00 | FDPS (1.00) | FDPSGGPS1BTN3A1CA12CA2 | |
| Zoledronic Acid Anhydrous SCHEMBL435847 | 1.00 | FDPS (1.00) | FDPSGGPS1BTN3A1CA12CA2 | |
| Zoledronic Acid Anhydrous SCHEMBL30422790 | 1.00 | FDPS (1.00) | FDPSGGPS1BTN3A1CA12CA2 | |
| Zoledronic Acid Anhydrous SCHEMBL536817 | 0.98 | FDPS (0.97) | FDPSGGPS1BTN3A1CA12CA2 | |
| Zoledronic Acid Anhydrous SCHEMBL28188462 | 0.98 | FDPS (0.97) | FDPSGGPS1BTN3A1CA12CA2 | |
| Zoledronic Acid Anhydrous SCHEMBL3007590 | 0.98 | FDPS (0.97) | FDPSGGPS1BTN3A1CA12CA2 | |
| Zoledronic Acid Anhydrous SCHEMBL3154439 | 0.98 | FDPS (0.97) | FDPSGGPS1BTN3A1CA12CA2 | |
| Zoledronic Acid Anhydrous SCHEMBL19054 | 0.98 | FDPS (1.00) | FDPSGGPS1BTN3A1CA12CA2 | |
| Zoledronic Acid Anhydrous SCHEMBL1586366 | 0.98 | FDPS (1.00) | FDPSGGPS1BTN3A1CA12CA2 | |
| Zoledronic Acid Anhydrous SCHEMBL22534391 | 0.96 | FDPS (0.96) | FDPSGGPS1BTN3A1CA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110551152-A | Preparation method of zoledronic acid monohydrate and anhydrate crystal forms | SICHUAN KELUN PHARM RES INST CO LTD | 2019-12-10 | — | — | CN | claimed |
| CN-107344950-A | A kind of zoledronic acid dihydrate compound | 天津市汉康医药生物技术有限公司 | 2017-11-14 | — | — | CN | claimed |
| CN-110551152-A | Preparation method of zoledronic acid monohydrate and anhydrate crystal forms | SICHUAN KELUN PHARM RES INST CO LTD | 2019-12-10 | — | — | CN | disclosed |
| CN-107344950-A | A kind of zoledronic acid dihydrate compound | 天津市汉康医药生物技术有限公司 | 2017-11-14 | — | — | CN | disclosed |
| CN-107344950-A | A kind of zoledronic acid dihydrate compound | 天津市汉康医药生物技术有限公司 | 2017-11-14 | — | — | CN | disclosed |
| CN-107344950-A | A kind of zoledronic acid dihydrate compound | 天津市汉康医药生物技术有限公司 | 2017-11-14 | — | — | CN | disclosed |
| US-8524912-B2 | Process for the preparation of [1-hydroxy-2-(1H-imidazol-1-yl)- ethylidene]bisphosphonic acid | ZAKLADY FARMACEUTYCZNE POLPHARMA SA (PL) | 2013-09-03 | — | — | US | disclosed |
| US-8524912-B2 | Process for the preparation of [1-hydroxy-2-(1H-imidazol-1-yl)- ethylidene]bisphosphonic acid | ZAKLADY FARMACEUTYCZNE POLPHARMA SA (PL) | 2013-09-03 | — | — | US | disclosed |
| US-20120116092-A1 | PROCESS FOR THE PREPARATION OF [1-HYDROXY-2-(1H-IMIDAZOL-1-YL)- ETHYLIDENE] BISPHOSPHONIC ACID | POLITECHNIKA GDANSKA (PL) | 2012-05-10 | — | — | US | disclosed |
| US-20120116092-A1 | PROCESS FOR THE PREPARATION OF [1-HYDROXY-2-(1H-IMIDAZOL-1-YL)- ETHYLIDENE] BISPHOSPHONIC ACID | POLITECHNIKA GDANSKA (PL) | 2012-05-10 | — | — | US | disclosed |
| EP-2350102-A1 | PROCESS FOR THE PREPARATION OF Ý1-HYDROXY-2-(1H-IMIDAZOL-1-YL)- ETHYLIDENE¨BISPHOSPHONIC ACID | Zaklady Farmaceutyczne Polpharma SA (PL) | 2011-08-03 | — | — | EP | disclosed |
| EP-2350102-A1 | PROCESS FOR THE PREPARATION OF Ý1-HYDROXY-2-(1H-IMIDAZOL-1-YL)- ETHYLIDENE¨BISPHOSPHONIC ACID | Zaklady Farmaceutyczne Polpharma SA (PL) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010050830-A1 | PROCESS FOR THE PREPARATION OF [1-HYDROXY-2-(1H-IMIDAZOL-1-YL)- ETHYLIDENE]BISPHOSPHONIC ACID | ZAKŁADY FARMACEUTYCZNE POLPHARMA SA (PL) | 2010-05-06 | — | — | WO | disclosed |
| WO-2010050830-A1 | PROCESS FOR THE PREPARATION OF [1-HYDROXY-2-(1H-IMIDAZOL-1-YL)- ETHYLIDENE]BISPHOSPHONIC ACID | ZAKŁADY FARMACEUTYCZNE POLPHARMA SA (PL) | 2010-05-06 | — | — | WO | disclosed |
| US-4939130-A | Substituted alkanediphosphonic acids and pharmaceutical use | CIBA-GEIGY CORPORATION (US) | 1990-07-03 | — | — | US | disclosed |