SCHEMBL23020146

SCHEMBL23020146

N#Cc1cc(-c2ccc(-c3ccccn3)cc2)cc(-c2cccc(-c3nc(-c4ccccc4)nc(-c4ccccc4)n3)c2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 13/20 0.53
CLK4 Q9HAZ1 2/20 0.49
ALDH1A3 P47895 1/20 0.43
MEN1 O00255 1/20 0.43
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
TSHR P16473 1/20 0.43
CYP2C19 P33261 1/20 0.43
KMT2A Q03164 1/20 0.43
HSD17B10 Q99714 1/20 0.43
ABCG2 Q9UNQ0 1/20 0.42
GABRA1 P14867 1/20 0.42
GABRG2 P18507 1/20 0.42
GABRB3 P28472 1/20 0.42
GABRA5 P31644 1/20 0.42
GABRA3 P34903 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23020094 1.00 GRM5 (0.53) GRM5CLK4ALDH1A3MEN1ALDH1A1
SCHEMBL23020433 1.00 GRM5 (0.53) GRM5CLK4ALDH1A3MEN1ALDH1A1
SCHEMBL23020096 1.00 GRM5 (0.53) GRM5CLK4ALDH1A3MEN1ALDH1A1
SCHEMBL23020170 0.96 GRM5 (0.56) GRM5CLK4MEN1ALDH1A1LMNA
SCHEMBL23020186 0.95 GRM5 (0.55) GRM5CLK4MEN1ALDH1A1LMNA
SCHEMBL23020185 0.95 GRM5 (0.55) GRM5CLK4MEN1ALDH1A1LMNA
SCHEMBL23020407 0.93 GRM5 (0.51) GRM5CLK4ALDH1A3ALDH1A1LMNA
SCHEMBL23020311 0.93 GRM5 (0.51) GRM5CLK4ALDH1A3ALDH1A1LMNA
SCHEMBL19020374 0.92 GRM5 (0.60) GRM5CLK4
SCHEMBL23020076 0.91 GRM5 (0.47) GRM5CLK4MEN1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3392242-B1 NOVEL HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE USING SAME LG CHEMICAL LTD (KR) 2021-02-24 EP disclosed