SCHEMBL2302116

SCHEMBL2302116

CCCC1=CC=C(CCC)[N]1

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 1/20 0.33
NOS1 P29475 1/20 0.33
NOS2 P35228 1/20 0.33
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
GAA P10253 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11898984 0.84
SCHEMBL22716012 0.73
SCHEMBL2764539 0.61
SCHEMBL27745811 0.58
SCHEMBL9797792 0.56 PDE3B (0.42) NOS2KDM4EALDH1A1GAAHPGD
SCHEMBL9797818 0.56 NOS2 (0.38) NOS3NOS1NOS2KDM4E
SCHEMBL6162687 0.56 MAPK1 (0.38) NOS3NOS1NOS2KDM4EALDH1A1
SCHEMBL9487271 0.56 HMGCR (0.42) NOS3NOS1NOS2ALDH1A1
SCHEMBL7700304 0.56 CNR1 (0.46) ALDH1A1HPGD
SCHEMBL11811150 0.56 HRH4 (0.38) NOS3NOS1NOS2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4759762-B2 2011-08-31 JP claimed
EP-0891331-B1 N-(2 OXOACETYL OR SULPHONYL)-PYRROLIDINE/PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY VERTEX PHARMA (US) 2003-10-01 EP claimed
EP-0891331-A1 N-(2 OXOACETYL OR SULPHONYL)-PYRROLIDINE/PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY Vertex Pharmaceuticals Incorporated (US) 1999-01-20 EP claimed
US-5717092-A Compounds with improved multi-drug resistance activity VERTEX PHARMACEUTICALS INC. (US) 1998-02-10 US claimed
WO-1997036869-A1 N-(2 OXOACETYL OR SULPHONYL)-PYRROLIDINE/PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY VERTEX PHARMACEUTICALS INCORPORATED (US) 1997-10-09 WO claimed
US-20240044876-A1 IDENTIFYING NEW THERAPEUTIC AGENTS WARP DRIVE BIO, INC. 2024-02-08 US disclosed
US-11644460-B2 Identifying new therapeutic agents Revolution Medicines, Inc. (US) 2023-05-09 US disclosed
US-10989710-B2 Identifying new therapeutic agents Revolution Medicines, Inc. (US) 2021-04-27 US disclosed
US-20190271691-A1 IDENTIFYING NEW THERAPEUTIC AGENTS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2019-09-05 US disclosed
US-10203323-B2 Identifying new therapeutic agents WARP DRIVE BIO, INC. (US) 2019-02-12 US disclosed
US-20160341719-A1 IDENTIFYING NEW THERAPEUTIC AGENTS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2016-11-24 US disclosed
US-9428845-B1 Identifying new therapeutic agents WARP DRIVE BIO, INC. (US) 2016-08-30 US disclosed
EP-0891331-B1 N-(2 OXOACETYL OR SULPHONYL)-PYRROLIDINE/PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY VERTEX PHARMA (US) 2003-10-01 EP disclosed
US-5935954-A TREATING THE PATIENT SUFFERING FROM PARKINSON'S DISEASE, ALZHIMER'S DISEASE, STROKE AND ISCHEMIA ASSOCIATED WITH STROKE, NEURAL PAROPATHY, SCIATIC CRUSH, SPINAL CORD INJURY OR FACIAL NERVE CRASH VERTEX PHARMACEUTICALS INCORPORATED (US) 1999-08-10 US disclosed
EP-0891331-A1 N-(2 OXOACETYL OR SULPHONYL)-PYRROLIDINE/PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY Vertex Pharmaceuticals Incorporated (US) 1999-01-20 EP disclosed
US-5717092-A Compounds with improved multi-drug resistance activity VERTEX PHARMACEUTICALS INC. (US) 1998-02-10 US disclosed
WO-1997036869-A1 N-(2 OXOACETYL OR SULPHONYL)-PYRROLIDINE/PIPERIDINE-2-CARBOXYLIC ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY VERTEX PHARMACEUTICALS INCORPORATED (US) 1997-10-09 WO disclosed