Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.60 |
| ▸ | NOS1 | P29475 | 4/20 | 0.50 |
| ▸ | AXL | P30530 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2611042 | 0.85 | IDO1 (0.55) | IDO1NOS1AXLTRPV1METAP2 | |
| SCHEMBL22079091 | 0.82 | IDO1 (0.53) | IDO1NOS1AXLTRPV1METAP2 | |
| SCHEMBL20353958 | 0.82 | IDO1 (0.53) | IDO1NOS1AXLTRPV1METAP2 | |
| SCHEMBL28592498 | 0.82 | IDO1 (0.53) | IDO1NOS1AXLTRPV1METAP2 | |
| SCHEMBL24630927 | 0.81 | IDO1 (0.59) | IDO1NOS1AXLTRPV1JAK2 | |
| SCHEMBL27550239 | 0.80 | IDO1 (0.55) | IDO1NOS1AXLTRPV1METAP2 | |
| SCHEMBL30162490 | 0.80 | IDO1 (0.55) | IDO1NOS1AXLTRPV1METAP2 | |
| SCHEMBL24285801 | 0.79 | IDO1 (0.50) | IDO1NOS1AXLTRPV1METAP2 | |
| SCHEMBL24368019 | 0.79 | IDO1 (0.54) | IDO1NOS1AXLTRPV1METAP2 | |
| SCHEMBL21540839 | 0.79 | IDO1 (0.54) | IDO1NOS1AXLTRPV1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032148-A1 | AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-02-25 | — | — | WO | disclosed |