Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.45 |
| ▸ | ATR | Q13535 | 9/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23021831 | 0.83 | ATR (0.49) | MAP4K1ATRPIK3CAPIK3CDPIK3R1 | |
| SCHEMBL23022112 | 0.79 | MAP4K1 (0.44) | MAP4K1ATRLRRK2PIK3CAPIK3CD | |
| SCHEMBL23021796 | 0.79 | MAP4K1 (0.48) | MAP4K1 | |
| SCHEMBL23021846 | 0.79 | ACVR2A (0.47) | MAP4K1ATRPIK3CAPIK3CDPIK3R1 | |
| SCHEMBL29507268 | 0.78 | ATR (0.54) | MAP4K1ATRCCNE2CCNE1CDK2 | |
| SCHEMBL23022177 | 0.78 | ATR (0.54) | MAP4K1ATRCCNE2CCNE1CDK2 | |
| SCHEMBL23022070 | 0.77 | MAP4K1 (0.48) | MAP4K1ATRLRRK2PIK3CAPIK3CD | |
| SCHEMBL30378197 | 0.77 | MAP4K1 (0.48) | MAP4K1ATRLRRK2PIK3CAPIK3CD | |
| SCHEMBL29507113 | 0.77 | MAP4K1 (0.48) | MAP4K1ATRLRRK2PIK3CAPIK3CD | |
| SCHEMBL22858879 | 0.77 | MAP4K1 (0.50) | MAP4K1ATRKCNH2LRRK2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032148-A1 | AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-02-25 | — | — | WO | disclosed |