Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 5/20 | 0.46 |
| ▸ | JAK1 | P23458 | 5/20 | 0.46 |
| ▸ | TYK2 | P29597 | 5/20 | 0.46 |
| ▸ | JAK3 | P52333 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TAF1 | P21675 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22858994 | 0.85 | MAP4K1 (0.69) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22859007 | 0.83 | MAP4K1 (0.49) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858740 | 0.79 | MAP4K1 (0.52) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858770 | 0.79 | MAP4K1 (0.75) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29608468 | 0.78 | MAP4K1 (0.43) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858763 | 0.78 | MAP4K1 (0.72) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL23021877 | 0.77 | MAP4K1 (0.45) | MAP4K1LRRK2PIK3CAKCNH2ATR | |
| SCHEMBL22858993 | 0.75 | MAP4K1 (0.66) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29609616 | 0.75 | MAP4K1 (0.66) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858802 | 0.74 | MAP4K1 (0.49) | MAP4K1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |