Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | MAP4K3 | Q8IVH8 | 2/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23022280 | 0.81 | — | — | |
| SCHEMBL23022279 | 0.81 | JAK1 (0.39) | AURKAAURKBMAP4K3GRK5 | |
| SCHEMBL23022319 | 0.78 | FGFR1 (0.30) | — | |
| SCHEMBL23022290 | 0.76 | JAK1 (0.35) | AURKAAURKBGRK5 | |
| SCHEMBL28734850 | 0.75 | LRRK2 (0.30) | — | |
| SCHEMBL23022209 | 0.75 | LRRK2 (0.38) | AURKBMAP4K3GRK5 | |
| SCHEMBL28734828 | 0.75 | MET (0.42) | GRK5 | |
| SCHEMBL24270064 | 0.75 | MAP4K3 (0.44) | MAP4K3GRK5 | |
| SCHEMBL23022183 | 0.74 | MET (0.36) | AURKAAURKB | |
| SCHEMBL23022232 | 0.74 | MET (0.41) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032148-A1 | AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-02-25 | — | — | WO | disclosed |