Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 17/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29515886 | 1.00 | ADRA2A (0.39) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL23107606 | 0.81 | CCR1 (0.34) | ALDH1A1 | |
| SCHEMBL25776758 | 0.78 | ADRA2A (0.33) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL20898129 | 0.78 | MAP4K1 (0.36) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL1191593 | 0.78 | MAP4K1 (0.34) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL26847661 | 0.77 | ADRA2A (0.34) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL25477287 | 0.77 | MAP4K1 (0.35) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL21334405 | 0.76 | MAP4K1 (0.46) | MAP4K1 | |
| SCHEMBL16079388 | 0.74 | MAP4K1 (0.36) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL23021748 | 0.74 | KDM4E (0.33) | ADRA2AADRA2CADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021032148-A1 | AMINOPYRAZINE COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-02-25 | — | — | WO | disclosed |